Cancer drug combo shows promise for patients resistant to standard treatments

Researchers discovered a promising leukemia drug breakthrough that could help patients overcome treatment resistance, offering hope for difficult AML cases.
Published: December 31, 2025, 7:16 pm
Older Americans are quitting GLP-1 weight-loss drugs for 4 key reasons

Nearly half of seniors quit GLP-1 weight-loss drugs within a year. Experts reveal why older Americans abandon medications like Ozempic and Wegovy despite results.
Published: December 31, 2025, 12:00 pm
The perfect day for parents: how to keep kids healthy and happy – without neglecting yourself

Having a routine but not overplanning, getting them involved with chores and making sure you have time just for you can all help you stop being overwhelmed
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My four-year-old is in the living room playing with a dinosaur, a pig and Jessie the cowgirl from Toy Story. I’m trying to cook dinner. “Mama, mama, pllleeease can you play with me?” I hear a pot lid rattle. The broccoli is starting to smell burned; I dash back to the kitchen. “Help! Quickly come! I’m falling!” I rush through. She’s dangling from the sofa pretending to fall off the side of a volcano. “HEEELP!” The broccoli is definitely burning. And there goes the door. “Muuuuuum, I need a poo!”
This wild ride of five minutes is one most parents will recognise. Getting through the day is to feel like you’re being pulled in a solar system’s worth of directions, and by turns defeated, happier than you’ve ever felt before, like a husk, in control and like you’re careening off a cliff. It throws up a need to get very good at planning, and prioritising what demands to acquiesce to, when to say no; when to sit down and play, when to say: “Sorry, I need to sit down, or go for a run.”
Continue reading...Published: January 1, 2026, 11:00 am
You be the judge: should my boyfriend change the way he showers?

Audrey thinks Noah doesn’t take bathing seriously enough. He says he’s a ‘quick-shower kind of guy’ but keeps himself clean. You decide whose argument scrubs up best
• Get a disagreement settled or become a YBTJ juror
Noah doesn’t wash himself thoroughly enough – he just rubs a bit of gel around his body
Continue reading...Published: January 1, 2026, 8:00 am
Don’t stress, do less: 52 ways to make your life easier in 2026

We asked experts in fields from homes to health to horticulture for advice on tasks we can simply stop doing and problems to take off our worry plates
The dawn of a new year brings visions of an idealised version of yourself. Fresh-faced, we eagerly pile our to-do lists with things we’ve been putting off and ambitions to aim for. But the energy that comes after a few days off quickly disappears as we settle back into the daily grind of school runs and inbox maintenance.
So instead of adding to your to-do list, why not resolve to take something off it?
Continue reading...Published: December 31, 2025, 2:00 pm
ITV agrees to invest £3m in fitness app created by Joe Wicks

The Body Coach app, launched in pandemic, will advertise on ITV’s channels and video platform ITVX under deal
The broadcaster ITV has agreed to invest up to £3m into the health and fitness app The Body Coach, created by Joe Wicks, who shot to fame by getting people exercising in their living rooms during the Covid pandemic.
It is the latest deal made through the group’s media for equity investment fund ITV AdVentures Invest. As part of the agreement, The Body Coach will advertise on ITV’s channels and its video platform ITVX.
Continue reading...Published: December 31, 2025, 3:35 pm
Bacterial Vaginosis Is No Longer Thought to Affect Only Women
Gynecologists long viewed bacterial vaginosis as solely a women’s issue — until a study that treated their male partners, too, proved otherwise.
Published: December 31, 2025, 7:08 pm
Childhood vaccines to be delivered at home in £2m bid to boost uptake

Under the scheme, health visiting teams will be able to vaccinate children as part of routine visits, rather than requiring families to attend GP surgeries.
Published: January 1, 2026, 8:20 am
Month by month, exactly what a year of sobriety does to the body, revealed by experts - as one in four of us plan to quit booze for Dry January

If you're one of the 17 million people expected to kickstart the year with a month-long break from booze, you might be inspired to extend it
Published: January 1, 2026, 7:00 am
Daily Mail graphic reveals the bottled waters with the most cancer-causing 'forever chemicals'

Bottled water is often viewed as a cleaner alternative to tap water, yet some of the leading bottled water brands contain dangerously high levels of enduring forever chemicals.
Published: January 1, 2026, 4:43 am
A 10-minute workout could help halt bowel cancer before it takes hold, say scientists

Even a short bout of exercise can trigger a rapid molecular change in the blood that helps stave off tumour progression, say scientists.
Published: January 1, 2026, 1:24 am
Five ways to slash cholesterol by a third WITHOUT statins. DR KIRSTYN NORMAN's tweaks work in as little as three months, protect against strokes and heart attacks, are drug-free - and change her patients' lives

As a doctor, I spent years caring for older patients whose lives were shaped by health problems that had quietly developed decades earlier.
Published: December 31, 2025, 10:00 pm
Surge in people visiting A&E for headaches, blocked noses, hiccups and other minor ailments, medics warn: 'The system isn't working'

Millions are clogging up A&Es across the country with minor ailments including blocked noses and hiccups due to the GP appointment crisis, experts have warned.
Published: December 31, 2025, 3:10 pm
The rise of 'heteroflexible': The fastest growing sexuality in the UK according to experts... do YOU meet the criteria?

There's still a few hours of 2025 left, meaning there's still time to add a new word to the national lexicon: Heteroflexible.
Published: December 31, 2025, 2:31 pm
Woman, 32, left with missing teeth after taking contraceptive injection prescribed to millions for 'too long'

A woman who lost half her teeth due to the contraceptive jab wants to warn others about the dangers of staying on the period-stopping medication for 'too long'.
Published: December 31, 2025, 2:30 pm
Cheers! Why champagne is one of the healthiest alcoholic drinks, revealed by experts

Forget church bells ringing, the real sound of a New Year being kicked off in style is the deafening "pop-pop-pop" of champagne corks.
Published: December 31, 2025, 1:08 pm
The dark truth about our obsession with 'high' protein: Our experts reveal the dangers of controversial powders, what having too much really does to your body... and the key nutrient you should be stocking up on instead

Are you eating enough protein? Food manufacturers certainly don't seem to think so.
Published: December 31, 2025, 12:06 pm
'Unsafe to drink' warning issued as Waitrose urgently recalls bottled water that could contain shards of glass

The supermarket said the products may pose a risk of injury if consumed and urged customers not to drink them.
Published: December 31, 2025, 11:15 am
Shock as mother delivers GIANT 'bowling ball' baby who weighs 13lbs and is the same size as a THREE MONTH old

A mother has shared her shock at giving birth to a baby who weighs the same as a bowling ball.
Published: January 1, 2026, 11:21 am
You can eat MORE and still lose weight: Experts explain how 'volume eating' can totally transform your health (and waistline) in 2026

The problem with traditional dieting is that it is largely focused on restricting calories, meaning we are often left feeling hungry, unfulfilled and ultimately unmotivated to keep going.
Published: January 1, 2026, 10:36 am
'Super' virus spreading uncontrollably... as New York sees most flu cases ever and experts warn 'we don't know when it will stop'

Cases of a 'super virus' are exploding across the US, with some states seeing more cases than ever before. Experts have also warned that there seems to be no end in sight for the surge.
Published: January 1, 2026, 1:38 am
I tried the $12 'miracle' hangover cure... but I made a critical mistake that left me full of regret

The hangover cure market is now valued at $2.3billion globally. But do these magic potions really work?
Published: December 31, 2025, 6:04 pm
How Ozempic is reshaping the American diet... Daily Mail graphs show how weight-loss drugs are changing what people buy at the grocery store

Blockbuster weight-loss drugs like Ozempic, Wegovy and Mounjaro are drastically changing what Americans are putting in their shopping carts, a new study and startling graphics have revealed.
Published: December 31, 2025, 4:00 pm
The surprising sign in your eyes that indicates if you'll get dementia later in life

Memory loss is the tell-tale sign that you or a loved one could be developing dementia. However, science shows your eyes could hold the first signs of the devastating disease years before diagnosis.
Published: December 31, 2025, 10:33 am
I did acupuncture to relieve my arthritis... but when my pain got worse an X-ray revealed a horrific side effect

Doctors in South Korea were taken aback when a 65-year-old patient's knee X-ray, intended to assess her arthritis, revealed numerous unexpected foreign objects embedded in the tissue.
Published: December 31, 2025, 5:50 am
Mysterious Dead Sea Scrolls code finally cracked revealing 2,000-year-old biblical writings

One of the last undeciphered Dead Sea Scrolls has been decoded, revealing biblical phrases and themes about the end of days.
Published: January 1, 2026, 9:09 am
Zohran Mamdani drops 'insane' list of items banned at NYC mayoral inauguration

New York City Mayor-elect Zohran Mamdani has released a list of items banned from his inaugural block party in New York City, which many people have called 'insane.'
Published: January 1, 2026, 1:32 am
Earthquake warnings flash from California to Nevada as near-5.0 quake rocks the West

Thousands of Americans received emergency alerts after an earthquake hit, telling them to 'Drop, cover, hold on.'
Published: December 31, 2025, 7:36 pm
The five unsolved mysteries of 2025 that captivated the world... from a UFO surviving a hellfire missile to a 'vast city' under Egypt's pyramids

Daily Mail reopens the most jaw-dropping mysteries which have yet to be solved as 2025 comes to a close.
Published: December 31, 2025, 6:55 pm
'World's craziest wave' leaves surfers in Australia baffled - as one jokes 'nature's gone AI'

From 73ft waves off Portugal to square waves in the Aegean Sea, several waves have left viewers baffled over the years. But the latest wave off the coast of Australia might be the most unusual one yet.
Published: December 31, 2025, 3:13 pm
The rise of 'heteroflexible': The fastest growing sexuality in the UK according to experts... do YOU meet the criteria?

There's still a few hours of 2025 left, meaning there's still time to add a new word to the national lexicon: Heteroflexible.
Published: December 31, 2025, 2:31 pm
Rubbish collection scheme on Mount Everest is scrapped after dishonest climbers found ways to cheat the system

A scheme to encourage climbers to bring rubbish down from Mount Everest has been scrapped, after dishonest mountaineers found ways to cheat the system.
Published: December 31, 2025, 2:12 pm
Cheers! Why champagne is one of the healthiest alcoholic drinks, revealed by experts

Forget church bells ringing, the real sound of a New Year being kicked off in style is the deafening "pop-pop-pop" of champagne corks.
Published: December 31, 2025, 1:08 pm
Want to impress with your cocktails this New Year's Eve? Scientist reveals the surprising secret to creating completely clear ice cubes - and it doesn't involve boiling water

Scientists have revealed a simple trick to produce completely clear ice cubes - and it could impress your guests this evening.
Published: December 31, 2025, 12:43 pm
Revealed: The most ANNOYING songs of 2025, according to science

Researchers from Seat Pick pulled the most popular songs of the year from the official charts, before running them through an 'annoyingness index'.
Published: December 31, 2025, 12:02 pm
Our ancestors were CANNIBALS: Scientists discover grisly evidence ancient human species ate Neanderthal children 45,000 years ago

Early humans may have feasted on Neanderthal children 45,000 years ago, according to a grisly new study.
Published: December 31, 2025, 11:25 am
Pilot reveals what turbulence looks like from the cockpit

Even for the most experienced fliers, turbulence can be unsettling. But according to a pilot, it's no more to worry about than bumps on a road.
Published: December 31, 2025, 10:33 am
Blind psychic Baba Vanga's prophecy reveals the exact year of humanity's 'absolute doomsday'

A blind psychic not only claimed to predict the end of humanity and the universe, but also laid out a detailed timeline of how it will happen.
Published: December 31, 2025, 8:53 am
Outrage as Bad Bunny violates sacred artifact at museum

Fans are outraged after seeing an image of Bad Bunny violating a sacred artifact housed in a museum, calling him 'ignorant' and 'privileged.'
Published: December 31, 2025, 1:09 am
Forget Rover, Buddy and Spot! Taylor Swift, Charli XCX and Elvis inspire the most popular pet names of 2025

Move over Buddy and Spot - Britain's pets are getting the A-list treatment, according to new research.
Published: January 1, 2026, 11:03 am
10 simple cybersecurity resolutions for a safer 2026

Learn how to act against cybercriminals in 2026 with essential security steps like two-factor authentication, software updates and credit freezing.
Published: December 31, 2025, 4:42 pm
2025 Most Memorable Technology Moments: December 31, 2025

Choose between OpenAI releasing Sora text-to-video model, the AI race heating up, or Waymo driverless cars launching in cities across the country
Published: December 31, 2025, 12:52 pm
Never lose your car with Maps parking tools

Learn how to set up Google Maps and Apple Maps on your phone to automatically remember where you parked. Step-by-step instructions for enabling location services and parking detection.
Published: December 31, 2025, 11:57 am
New York to Phase In Protections for Horseshoe Crabs

Gov. Kathy Hochul signed legislation that will ultimately ban the catch and biomedical use of the crabs.
Published: January 1, 2026, 10:01 am
Even the Sky May Not Be the Limit for A.I. Data Centers

Some tech leaders are concerned that the artificial intelligence race will exhaust available land and energy. The solution might lie in orbit.
Published: January 1, 2026, 10:00 am
90 Minutes to Give Baby Luna a New Heart

After eight years of training, Dr. Maureen McKiernan made her debut as the lead surgeon on an infant heart transplant — an operation on the edge of what’s possible.
Published: January 1, 2026, 10:00 am
Research Library at NASA’s Goddard Space and Flight Center to Close Friday

Holdings from the library at the Goddard Space Flight Center, which includes unique documents from the early 20th century to the Soviet space race, will be warehoused or thrown out.
Published: December 31, 2025, 10:58 pm
Bacterial Vaginosis Is No Longer Thought to Affect Only Women
Gynecologists long viewed bacterial vaginosis as solely a women’s issue — until a study that treated their male partners, too, proved otherwise.
Published: December 31, 2025, 7:08 pm
Elon Musk’s 2025 recap: how the world’s richest person became its most chaotic

How the tech CEO and ‘Dogefather’ made a mess of the year – from an apparent Nazi salute during his White House tenure to Tesla sales slumps and Starship explosions
The year of 2025 was dizzying for Elon Musk. The tech titan began the year holding court with Donald Trump in Washington DC. As the months ticked by, one public appearance after another baffled the US and the world. Musk appeared to give a Nazi salute at Trump’s inauguration, staunchly championed a 19-year-old staffer nicknamed “Big Balls,” denied reports of being a drug addict while advising the president, and showed up at a White House press conference with a black eye – all in the first half of the year alone.
“Elon’s attitude is you have to get it done fast. If you’re an incrementalist, you just won’t get your rocket to the moon,” Susie Wiles, Trump’s chief of staff, told Vanity Fair in an expansive interview earlier this month. “And so with that attitude, you’re going to break some china.”
Continue reading...Published: December 31, 2025, 1:00 pm
Tesla publishes analyst forecasts suggesting sales set to fall

Tesla endured tough year in part thanks to some consumers’ distaste for Elon Musk’s embrace of rightwing politics
Tesla has taken the unusual step of publishing sales forecasts that suggest 2025 deliveries will be lower than expected and future years’ sales will be well below targets set by its chief executive, Elon Musk.
The US electric vehicle maker published figures from analysts suggesting it will announce 423,000 deliveries during the fourth quarter of 2025, in a new “consensus” section on its investor website. That would represent a 16% decline from the final quarter of 2024.
Continue reading...Published: December 31, 2025, 4:24 pm
The best cross trainers for a low-impact workout at home, tested

New year fitness goals? An elliptical will put you through your paces without the joint strain – our reviewer worked up a sweat testing the best
A quick admission: I absolutely love an elliptical or cross trainer. They don’t always get the plaudits they deserve, but these low-impact cardio machines not only put less strain on your joints than a treadmill but also help you get an impressive, full-body workout. Whether you hop on one to warm up before an intense strength-training session or use it to gently burn calories while listening to your favourite podcast, the elliptical or cross trainer can strengthen muscle, reduce fat and improve cardiovascular fitness.
However, there is a catch in that these machines vary wildly in their design – and therefore the emphasis they place on different muscles. Traditional elliptical machines eschew moving handles, instead opting for static poles, while cross trainers usually have dynamic handles that recruit the muscles in your back, shoulders and arms. On top of this, stride length, the shape of the handles and the positioning of the footplates can make a big difference to the type of workout you’ll have.
Best cross trainer overall:
BowFlex Max Trainer M6
Best value elliptical trainer:
Horizon EX-59
Published: December 31, 2025, 3:00 pm
Roblox, James Bond and a billion-dollar multiplayer – here are our most-read gaming stories of 2025

In this week’s newsletter: The year’s most popular stories reveal how play, power and politics collided in the past 12 months – and what you’re psyched for in 2026
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With the best games of the year duly noted (yours and ours), I’d like to highlight some of the work we’ve done covering them. Reviewing the top-performing articles that we published in 2025, I see a portrait of a conflicted year: plenty of great works and games that captured the imagination and the world’s attention, but also growing anxiety about their place in the real world, and the political circumstances they reflect. And a lot of (justified) hand-wringing over Roblox.
But first: I wanted to extend heartfelt thanks to everyone who reads this newsletter and the rest of our work at the Guardian. If you’ve enjoyed our coverage, do consider supporting us to do more of it – either through a recurring or one-off contribution. Without your support, none of the great journalism we produce would be possible. Thank you for being with us in 2025, and I hope you stick around to watch me slowly lose my mind working overtime in the buildup to Grand Theft Auto 6’s release in November 2026. (Finally).
Continue reading...Published: December 31, 2025, 12:30 pm
The man taking over the Large Hadron Collider – only to switch it off

Next head of Cern backs massive replacement for world’s largest machine to investigate mysteries of the universe
Mark Thomson, a professor of experimental particle physics at the University of Cambridge, has landed one of the most coveted jobs in global science. But it is hard not to wonder, when looked at from a certain angle, whether he has taken one for the team.
On 1 January, Thomson takes over as the director general of Cern, the multi-Nobel prizewinning nuclear physics laboratory on the outskirts of Geneva. It is here, deep beneath the ground, that the Large Hadron Collider (LHC), the largest scientific instrument ever built, recreates conditions that existed microseconds after the big bang.
Continue reading...Published: December 31, 2025, 12:00 pm
Rage bait, goblin mode … do words of the year have any real value?

Analysis shows obscure and barely used choices, drawn from online slang, do not stand the test of time
If you have seen a news story declaring 2025’s chosen “word of the year” in recent weeks, you might be forgiven for asking yourself: what, another one?
Depending on which dictionary you turn to, the chosen term this year was either Collins’s “vibe coding”, “parasocial” from Cambridge Dictionaries or their Oxford University Press rival’s “rage bait” – with many other selections besides.
Continue reading...Published: December 31, 2025, 10:39 am
The WHO learned to love ‘anti-obesity’ jabs in 2025. I don’t fully agree, but I get it | Devi Sridhar

While GLP-1 drugs promise an easy fix, our bodies still need what they have always needed: healthy food and regular exercise
Prof Devi Sridhar is chair of global public health at the University of Edinburgh
If there has been a hot topic in health in 2025, it’s definitely been GLP-1s, colloquially referred to as “anti-obesity” jabs. These medications, taken weekly as an injection into the abdomen, result in significant weight loss and, despite being developed to manage type 2 diabetes in those with metabolic disorders, have become mainstream in many countries as a treatment for obesity. Clinicians rave about the health outcomes in patients taking the medication, with study after study emerging on the health benefits of the associated weight loss in those who are obese. Celebrity endorsements, online sales and off-label use have seen them widely used by people of all ages and sizes who want to drop weight.
For the public health community, it’s an odd moment. For years, we’ve advocated for government action on obesity – not through new drugs, but by taking nutrition and food systems seriously. We’ve highlighted the need for government action on making nutritious food affordable, regulating ultra-processed foods, bringing in sugar taxes and banning advertising of unhealthy products to young people, alongside encouraging an increase in physical activity. The solutions are simple: get people to eat more nutritious food and move. The challenge has been implementation, especially in deprived areas.
Prof Devi Sridhar is chair of global public health at the University of Edinburgh
Fit Forever: Wellness for midlife and beyond
On Wednesday 28 January 2026, join Annie Kelly, Devi Sridhar, Joel Snape and Mariella Frostrup, as they discuss how to enjoy longer and healthier lives, with expert advice and practical tips. Book tickets here or at guardian.live
Published: December 31, 2025, 1:13 pm
‘They didn’t de-extinct anything’: can Colossal’s genetically engineered animals ever be the real thing?

The bioscience startup has attracted billions in investment – and a flurry of criticism, but founder tells the Guardian plans to bring back the woolly mammoth will not be derailed
Death and taxes are supposed to be the things we can depend on in this life. But in 2025, the American entrepreneur Ben Lamm sold much of the world on the idea that death did not, after all, need to be for ever.
This was the year the billionaire’s genetics startup, Colossal Biosciences, claimed it had resurrected the dire wolf, an animal that disappeared at the end of the last ice age, by tweaking the DNA of grey wolves. According to the company, it had also edged closer to bringing the woolly mammoth back from the dead, with the creation of genetically engineered “woolly mice”.
Continue reading...Published: December 31, 2025, 11:00 am